The Effect of Magnetic Iron Oxide Nanoparticles on Mice Liver and Kidney
سال انتشار: 1391
نوع سند: مقاله ژورنالی
زبان: فارسی
مشاهده: 35
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شناسه ملی سند علمی:
JR_JKMU-19-4_003
تاریخ نمایه سازی: 14 اسفند 1402
چکیده مقاله:
Background & Aims: In spite of frequent produce and use of magnetic nanoparticles in biological fields, there are few studies on their side effects, especially under in-vivo conditions. Method: In this research, the effect of the single-dose intraperitoneal injection of DMSA (dimercaptosuccinic acid) coated magnetic iron oxide nanoparticles (Fe۳O۴) in different doses (۵۰, ۱۰۰, ۲۰۰ and ۳۰۰ mg/kg) on liver and kidney function was studied. Results: Clusters of iron oxide nanoparticles were observed in treatment mice liver and kidney tissues as dark blue accumulations with Prussian blue staining up to ۴ days after administration; so, the nanoparticles were absorbed into and were accumulated in these organs. No histological disorders were observed in the tissue sections in comparison with controls. Considering biochemical analysis, the mean amounts of SGOT, SGPT, and LDH enzymes, also albumin, uric acid, urea and creatinine were not different significantly than control group; but in contrast to the control group, the mean numbers of the blood cells were decreased significantly in treatment groups with doses higher than ۵۰ mg/kg. During the study, no death was found in animals. Conclusion: The data suggest that the future applications of DMSA- coated magnetic iron oxide in medicine and biology has not probably toxic effects on health human.
کلیدواژه ها:
Magnetic iron oxide nanoparticles ، Dimercaptosuccinic acid ، Absorption ، kidney ، Liver ، ، Toxicity
نویسندگان
A Nori
Assistant Professor of Developmental Biology, Department of Biology, Falavarjan Branch, Islamic Azad University, Isfahan, Iran
GH.R Amiri
Assistant Professor of Physics, Falavarjan Branch, Islamic Azad University, Isfahan, Iran
B Taj
Bachelor of Science in Biochemistry
M Nasreesfahani
Bachelor of Science in Biochemistry
S Taj
Bachelor of Science in Biochemistry
A Valiyani
Instructor, Dep. Anatomical Sciences and Molecular Biology, Isfahan University of Medical Sciences, Isfahan, Iran