Prevalence of Sputnik V COVID-۱۹ Vaccine Side Effects Among Healthcare Workers in a Tertiary Care, Academic Center in Tehran City, Iran

Background and Purpose: COVID-۱۹ vaccine side effects predominantly affect public confidence in vaccination. Therefore, this study evaluated the rate and severity of adverse reactions associated with the COVID-۱۹ Sputnik V vaccine among tertiary healthcare providers in an academic medical center. Materials and Methods: This retrospective observational study was carried out from March ۲۰۲۱ to August ۲۰۲۱ among Imam Khomeini Hospital Complex healthcare workers, a tertiary referral healthcare center affiliated with Tehran University of Medical Sciences. Participants provided demographic and clinical information through a validated questionnaire after being interviewed. The frequency, severity, and outcome of all reactions after vaccination were recorded. The study utilized SPSS software, version ۲۴.۰ to conduct descriptive statistics on baseline variables and inferential statistics to examine associations between vaccine side effects and gender, medical history, and COVID-۱۹ history of the participants. Additionally, ordinal regression analysis was employed to identify factors predicting the severity of adverse effects after the first and second doses of the Sputnik V vaccine. Results: A total of ۳۷۲ participants (۵۴.۳% female) with a mean age of ۳۶.۵±۹.۱۸ years were recruited. The rate of at least one side effect was ۷۷.۱۵% and ۵۷.۸% after the first and second doses, respectively. The most common side effects among participants were myalgia (۴۸.۴% after the first and ۲۸.۲% after the second dose), injection site pain (۲۶.۳% after the first and ۱۲.۶% after the second dose), and fever (۱۹.۶% after the first and ۱۲.۹% after the second dose). The higher rate of fever and myalgia after the first dose was observed among subjects with a history of COVID-۱۹.  Conclusion: Among healthcare workers, the side effects following the first and second doses of the Sputnik V vaccine were primarily mild, with no cases requiring hospitalization. Further research is required to assess potential side effects in larger and diverse populations with varying demographic and social characteristics.

کلیدواژه ها:

COVID-۱۹ vaccine ، Adverse reactions ، Healthcare workers