Identification of Common Hub Genes and Key Molecular Pathways between Multiple Sclerosis and Urological Disorders

Introduction: The immune system plays a vital role in affording protection for the body against a wide variety of diseases and infections. On occasion, the system malfunctions and attacks intact cells, tissues, and organs influencing any part of the body, tapering off bodily function, and leading to life-threatening. multiple sclerosis (MS) is characterized by inflammatory demyelination with a diverse range of urologic indications.Methods: To extract the overlapped genes and single-nucleotide polymorphisms (SNPs; until November ۲۰۲۲) between MS and several urological disorders, we searched the DisGeNET database. Furthermore, to identify significant Gene Ontology (GO) terms and the Kyoto Encyclopedia of Genes and Genome (KEGG) pathway, the Enrichr assessment was used.  Additionally, in the case of overlapped genes, the maximum level of linkage hub genes was investigated by the protein-protein interaction (PPI) network construction via cytoHubba.Results: ۱۳۶۲ common genes between MS and urological disease were recognized, of which ۱۵۴ genes have SNPs linked with MS susceptibility. Three DisGeNET-indexed MS-associated SNPs, including rs۶۵۳۱۷۸, rs۱۰۹۳۶۵۹۹, and rs۴۹۷۶۶۴۶ were shared between MS and urological disorders. TNF, AKT۱, IL۱B, IL۶, VEGFA, INS, C-C CCL۵, TP۵۳), RELA proto-oncogene, STAT۳, and EGFR were detected as hub genes overrepresented in the identified pathways.Conclusion: Of ۱۳۶۲ common genes, ۱۱ key genes, and ۳ SNPs were shared between MS and urology-related diseases. These identified features might serve as potential therapeutic targets in both disorders, with a probable role in the management of urological complications in MS patients.

کلیدواژه ها:

single-nucleotide polymorphisms ، Gene Expressions ، Molecular Pathways ، Multiple Sclerosis ، Urological diseases