Study on pathogenic role of Demodex mites in Several diseases

BACKGROUND AND ABJECTIVEThe skin is the human body’s largest organ, colonized by a diverse milieu of microorganisms, most of which are harmless or even beneficial to their host. Demodex folliculorum and Demodex brevis are two species of tiny parasitic mites that live in the hair follicles and sebaceous glands of human skin, respectively Demodex has been considered to be related with multiple skin disorders, but controversy persists. Demodex mites play an important role in the occurrence of diseases such as seborrheic dermatitis, rosacea, acne vulgaris, itching and hair loss.MATERIALS AND METHODSIn this case-control study, the prevalence of Demodex mites was studied in facial biopsy of ۱۰۰ patients with rosacea, ۹۰ patients with seborrheic dermatitis, ۸۵ patients with acne, ۱۰۰ patients with hair loss and ۶۵ patients with itching. direct microscopic examination was done from ۱ cm۲ of facial skin and scalp sebum. Some references consider the density of more than five mites per cm۲ as a pathogenic criterion.RESULTS AND DISCUSSION we have separately investigated the relationship between Demodex mites and skin diseases such as rosacea, seborrheic dermatitis, hair loss, itching and acne. The prevalence of Demodex mites in patients with rosacea, seborrheic dermatitis, acne, hair loss and itching were ۸۴%, ۷۲%, ۵۲% and ۶۰%, respectively. complications had significantly higher prevalence and degrees of Demodex mites contamination compared to control patients.CONCLUSIONDemodex mites live inside almost every human’s hair follicles. The mites usually don’t cause any problems, but if they multiply too much, they can cause demodicosis. Developing Demodex mites may be causative agents of occurrence skin diesases through various mechanisms: They may mechanically block hair follicles, secrete digestive enzymes, Destroy the epithelial barrier, Trigger reactions of the immune system. According to our study. the prevalence of Demodex mites in patients with rosacea (۸۴%) was significantly higher than the patients with seborrheic dermatitis, acne, hair loss, itching. So Demodex mites can play an important role in the etiology of these diesases specially rosacea

کلیدواژه ها:

Demodex ، diseases of Demodex