The in vitro anti-Leishmania effect of medicinal plants on the promastigote of Leishmania major

BACKGROUND AND OBJECTIVESleishmania are protozoan parasites that affect approximately ۲ million people worldwide. Current treatment for cutaneous leishmaniasis is not completely satisfactory and involves the use of pentavalent antimonies. However, chemical drugs have limitations due to disease relapse, drug resistance and severe side effects. Recently, the use of alternative treatments from medicinal plants has increased.MATERIALS AND METHODSIn this study, scientific databases such as PubMed, Science Direct, Google Scholar and domestic scientific databases in Iran have been studied from ۲۰۰۹ to ۲۰۲۱.RESULTS AND DISCUSSIONIn studies conducted, medicinal plants such as Cymbopogon species, Lippia sidoides Cham, Allium cepa, Zingiber officinale, Osmium gratissimum and Artemisia species have shown activity in inhibiting the growth of promastigotes. This herbs not significantly effective, when used alone. Changing the extraction methods or combining them with other drugs, may improve their efficacy. Some of these plants can also be used as a complementary treatment.CONCLUSIONMedicinal plants can have a significant impact on the treatment and reduction of side effects from cutaneous leishmaniasis. These herbs can be used as alternative treatment to chemical drugs. However, further studies are needed to in-vivo evaluation.

کلیدواژه ها:

Cutaneous lishmaniasis ، Herbal medicine ، Promastigote