Seroconversion age of EBV among children under ۱۰ years in Mashhad

BACKGROUND AND ABJECTIVEEpstein-Barr virus, also known as Human gammaherpesvirus ۴, is one of the eight known viruses belonging to the herpesvirus family. The virus can infiltrate a multitude of cells, including B lymphocytes and epithelial cells. Researchers have conducted research on the age of seroconversion and its correlation to B lymphocyte malignancies in children in various geographical regions because of the significance of the Epstein-Barr virus.Our community's data shortages on the infection rate of the infection at the primary age of seroconversion spotlight the requirement for further research. This study endeavors to investigate the age of seroconversion for children aged ۱۰ and under in Mashhad.MATERIALS AND METHODSWe investigated at Imam Reza, Akbar, and Qaim Hospital, where ethical regulations and protocols were strictly enforced during the sampling procedure. We collected the samples from the leftover serum of children who had routine tests done at the Qaim and Akbar special clinics. For confidentiality, we took ۲۸۳ serum specimens at random from children no older than ۱۰ years, with their names, ages, and sex codes kept secret. The samples were divided evenly between the two sexes and were subsequently tested using the EBV antibody ELISA test kit.RESULTS AND DISCUSSIONThe study evaluated ۲۸۳ children below ۱۰ years of age, with ۵۹.۲% being boys, ۴۰.۸% girls, and gender information missing for six children. Among them, ۲۹% tested positive for the EBV antibody. We observed the lowest frequency of positive results in the age group with the least amount of antibodies. The age group with the highest frequency of positive results was under six months, with ۵۵.۶%, while the age group between ۷-۱۰ years recorded the lowest frequency of ۶.۵%. Statistical analysis revealed a significant difference between age groups, while we observed no significant difference based on gender.CONCLUSIONOut of the children examined,% ۲۹ had an EBV antibody in their system. Analysis of positive results based on age groups showed the highest frequency in children below six months of age (۵۵.۶%) and the lowest frequency in the age group of ۷-۱۰ years (۶.۵%). A significant difference was observed between different age groups, while no significant difference was found based on gender. The study identified the age of seroconversion to be between ۳-۴ years old.

کلیدواژه ها:

Seroconversion ، EBV ، Elisa