Urinary tract infection by corynebacterium urealyticum

BACKGROUND AND ABJECTIVEcorynebacterium urealyticum is a gram positive, slow growing, urease positive and microorganism with a diphteroid morphology. This organism has long been recognized as a uropathogen because of its urease activity, which play an important role in the pathogenesis of UTIs , resulting in the alkalinization of urine , further leading to encrusted cystitis or struvite stone formation. The risk factors constituate the elderly age group, immunosuppression, urological procedure, prior broad spectrum antibiotic therapy. C.urealyticum being a known multi drug resistant organism. Its treatment with the right antibiotic becomes significant, as failure in therapy leads to persistent infections. We report here case of C. urealyticum which caused uncomplicated UTI in a young patient with clept lip case report.MATERIALS AND METHODSA ۷ years old child with prenorbid conditions ultra red in near clinical laboratory. These patients suffer from dysuria and frequency and urgency of urination. The organism grows on Blood agar as pinpoint colonies after ۴۸ hours of incubation at ۳۵-۳۷º C. Colonies are withish, opaque, smooth , convert, circula and non hemolytic. This bacteria is strongly urease positive .Antimicrobial susceptibility showed susceptibility to all β-lactams and was sensitive to vancomycin.RESULTS AND DISCUSSIONGrowth in pure culture or as predominant flora, especially if see with polymorphonuclear cells in gram stained samples is of great value. Most C. urealyticum isolates are missed in routine urine culture because the organism does not growth after overnight incubation. For diagnosing human infections caused by C. urealyticum strong collaboration between microbiologist and infectious diseases or urologist is necessary. The prognosis for patients with infection caused by C. urealyticum appears to be reasonably good.

کلیدواژه ها:

Corynebacterium Urealyticum ، Urinary Tract Infection ، Struvite Stone