Evaluate of tetracycline-resistant genes among Shiga-toxin-producing Escherichia coli (STEC) strains from diarrheic human cases in Kerman

BACKGROUND AND OBJECTIVESInfectious diarrhea, one of the most common syndromes of gastrointestinal infections, is caused by several bacterial agents. Escherichia coli (E. coli) could be considered one of the most prevalent bacterial species of gastrointestinal infections. This study aimed to evaluate the presence of tetracycline-resistant genes among Shiga-toxin-producing E. coli (STEC) strains from diarrheic human cases in Kerman, southeast of Iran.MATERIALS AND METHODSIn this study, ۳۹ Shiga-toxin-producing E. coli (STEC) strains from people with diarrhea were screened for the presence of tetracycline genes by conventional polymerase chain reaction (PCR).RESULTS AND DISCUSSIONOut of the ۳۹ analyzed samples, one sample (۰.۳۹%) were positive for tatA gene, and ۱۰ (۳%) for tetB gen.CONCLUSIONThis study showed the presence of antimicrobial resistance genes encoding tetA and tetB in diarrheal strains of E. coli in southeast Iran. Therefore, there is a need to increase surveillance in hospitals and reduce indiscriminate antibiotic prescribing to reduce the prevalence of antibiotic-resistant E. coli.

کلیدواژه ها:

Escherichia coli ، Diarrhea ، Antibiotic resistance genes ، tetracycline genes