Prevalence and molecular epidemiology of ceftaroline non-susceptible methicillin-resistant Staphylococcus aureus isolates, first clinical report from Iran
سال انتشار: 1402
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 135
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شناسه ملی سند علمی:
MEDISM24_448
تاریخ نمایه سازی: 6 اسفند 1402
چکیده مقاله:
BACKGROUND AND OBJECTIVESMethicillin-resistant Staphylococcus aureus (MRSA) is one of the major pathogens in Iran with a high prevalence and a high level of antibiotic resistance. Ceftaroline is a fifth generation cephalosporin binding and inhibiting penicillin binding protein (PBP۲a).MATERIALS AND METHODSIn the present study, ۲۲۸ clinical MRSA isolates were collected from four cities of Iran and their susceptibility to ceftaroline was evaluated by E-test and the disk diffusion method.RESULTS AND DISCUSSIONOur results showed a high susceptibility rate (۹۷.۳%) to ceftaroline in MRSA strains from Iran. Six isolates were found to be ceftaroline non-susceptible (CPT-NS) with Minimum inhibitory concentration (MIC) ≥۲ mg/mL. All CPT-NS isolates were isolated from blood and tracheal aspirate and belonged to SCCmec type III as well as agr type I and were all susceptible to vancomycin. Out of six isolates, three, two and one belonged to spa type t۰۳۰, t۴۸۶۴, and t۹۶۹, respectively. Vancomycin, quinupristin/dalfopristin, linezolid, chloramphenicol, and tigecycline were the most active agents against CPT-NS isolates.CONCLUSIONDue to the broad-spectrum activity and low toxicity of ceftaroline as well as the increased rate of vancomycin resistance among MRSA strains in recent years, ceftaroline can be considered as a novel approach to treat MRSA-induced infections
کلیدواژه ها:
نویسندگان
Amin Khoshbayan
Department of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
Aref Shariati
Molecular and Medicine Research Center, Khomein University of Medical Sciences, Khomein, Iran
Ehsanollah Ghaznavi-Rad
Department of Medical Laboratory Sciences, Arak School of Paramedicine, Arak University of Medical Sciences, Arak, Iran
Davood Darban-Sarokhalil
Department of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran