Investigation of the antibiotic susceptibility pattern of carbapenem-resistant Klebsiella pneumoniae isolated from patients at Pars General Hospital, Tehran, Iran

BACKGROUND AND OBJECTIVESGiven the spread of antibiotic resistance and the increasing infections caused by Gram-negative bacilli over the past few years, a study was conducted to examine the antibiotic susceptibility pattern in carbapenem-resistant Klebsiella pneumoniae from hospitalized and outpatient individuals visiting Pars General Hospital, Tehran, Iran.MATERIALS AND METHODSIn the conducted study, all patient culture results, sample types, admission types, patient ages, and patient genders from February ۲۰۲۲ to July ۲۰۲۳ were extracted and analyzed using SPSS software.RESULTS AND DISCUSSIONApproximately half of the carbapenem-resistant Klebsiella pneumoniae isolates in this study (۵۱.۱%) were from individuals aged ۶۵ and older, and most cases (۷۷.۸%) were from outpatient attendees. The frequency of isolation based on clinical sample type was related to wounds (۴۰%), urine (۳۵.۶%), sputum (۱۵.۶%), catheters (۴.۴%), bronchoalveolar lavage (۲.۲%), and ascetic fluid (۲.۲%). The highest antibiotic susceptibility was observed for tigecycline (۸۷.۵%), colistin and polymyxin B (۸۵%), followed by doxycycline (۶۵%) and tetracycline (۶۴.۱%). While susceptibility to other tested antibiotics (amikacin, cefixime, cephalexin, cefotaxime, ceftazidime, cefazoline, cefepime, ceftriaxone, ciprofloxacin, levofloxacin, norfloxacin, ertapenem, imipenem, meropenem, ampicillin, amoxicillin, gentamicin, tobramycin, piperacillin-tazobactam, trimethoprim-sulfamethoxazole, ampicillin-sulbactam, aztreonam, minocycline, nitrofurantoin, and chloramphenicol) ranged from zero to ۲۰.۵%. Our findings in this study indicate the highest antibiotic sensitivity in carbapenem-resistant Klebsiella pneumoniae to tigecycline, colistin, and polymyxin B, aligning with other studies conducted in this field.CONCLUSIONThe results of these studies demonstrate high resistance incident of carbapenem-resistant Klebsiella pneumoniae to most available antibiotics, which is significant in the treatment of patients infected with this microorganism

کلیدواژه ها:

Antibiotic Resistance ، Carbapenem ، Klebsiella pneumoniae