Colistin susceptibility in Carbapenem resistant Enterobacteriaceae isolates from wound infections, Tabriz, Iran

BACKGROUND AND OBJECTIVESThe present study was aimed to study colistin susceptibility in Carbapenem resistant Enterobacteriaceae (CRE) isolated from wound infections.MATERIALS AND METHODSTwo hundred and five Enterobacteriaceae were isolated from wound infection during ۲۰۲۱-۲۰۲۳. The disk diffusion assay was performed according to the Clinical and Laboratory Standards Institute (CLSI)- established breakpoints. The colistin and meropenem MIC (Minimum Inhibitory Concentration) was determined by the micro-broth dilution according to CLSI guidelines.RESULTS AND DISCUSSIONAmong the ۲۰۵ Enterobacteriaceae, ۶۱ isolates (۲۹.۷۵%) were CRE included Klebsiella pneumoniae (۳۹/۶۱; ۶۳.۹۳%) followed by Escherichia coli (۱۸/۶۱: ۲۹.۵۰%), and Enterobacter spp (۴/۶۱; ۶.۵۵%). All carbapenem resistant isolates were MDR. The colistin MIC range was ۰.۱۲ to ۱۶ μg/mL. Two K. pneumoniae isolates (۵.۱%) were colistin resistant. The colistin MIC ۵۰ and MIC۹۰ were ۰.۲۵ and ۱ μg/mL, respectively.CONCLUSIONColistin may be an alternative antimicrobial agent for infections due CRE. However, Colistin susceptibility should be studied before its usages in antimicrobial therapy.

کلیدواژه ها:

Carbapenem ، Colistin ، Enterobacteriaceae ، Multi- Drug Resistance