Carbapenems resistant Enterobacteriaceae isolated from wounds infections from Tabriz, Iran

BACKGROUND AND OBJECTIVESThis study was aimed to investigate antibiotic susceptibility patterns and carbapenem resistance mechanisms of Enterobacteriaceae isolated from wound infections of Tabriz during ۲۰۲۱-۲۰۲۳.MATERIALS AND METHODSTwo hundred and five Enterobacteriaceae isolated was isolated from wound infections. The disk diffusion and microbroth dilution methods were applied for determine the antibiotics susceptibility patterns. Carbapenemase mediated resistance mechanisms were detected by modified carbapenem inactivation method (mCIM). The carbapenemase genes were detected by the PCR method.RESULTS AND DISCUSSIONAccording to the antimicrobial susceptibility testing, a high level of resistance was observed to different class of antibiotics except colistin and amikacin. Among carbapenem resistant isolates, Klebsiella pneumoniae was most common (۳۹/۶۱; ۶۳.۹۳%) followed by Escherichia coli (۱۸/۶۱: ۲۹.۵۰%), and Enterobacter spp (۴/۶۱; ۶.۵۵%). AmpC overexpression was detected in all Enterobacter spp isolates. According to the mCIM and PCR results, E. coli and K. pneumoniae were carbapenem resistance due to carbapenemase production. The most common carbapenemase gene was blaOXA-۴۸-like (۴۹.۱۲%) followed by blaKPC (۲۶.۳۱ %) blaNDM (۲۱.۰۵ %), and blaVIM (۳.۵%).CONCLUSIONThe frequency of carbapenems resistant Enterobacteriaceae in our setting is at a worrying level. The most common mechanism of resistance to carbapenems was carbapenemase. We suggest revision in the controlling program of wound infections caused Enterobacteriaceae in our hospitals.

کلیدواژه ها:

Wound infections ، Carbapenem ، Enterobacteriaceae