Cure of h.pylori with probiotics

BACKGROUND AND OBJECTIVESHelicobacter pylori is a bacterium that can cause gastrointestinal disorders such as peptic ulcer and gastric cancer. Antibiotics are the primary treatment for H. pylori infection, but the increasing resistance to antibiotics has led to the investigation of alternative treatments such as probiotics. Probiotics are live microorganisms The most commonly used probiotic bacteria are Lactobacillus and Bifidobacterium. The main objective of using probiotics in the treatment of H. pylori infection is to improve the eradication rate of the bacterium and reduce the side effects of antibiotics.MATERIALS AND METHODSObtaining probiotics from different types of bacteria requires different methods and materials. Encapsulation techniques have attracted great interest because they encapsulate a material in a polymeric membrane matrix without affecting its biological activity. We can use probiotics alone or in addition to conventional therapy. The effect of probiotics on H. pylori gastritis is commonly measured by rapid urease testing, respiratory urea testing (UBT), serological testing, fecal antigen testing, and histological examination of gastric biopsies.RESULTS AND DISCUSSIONProbiotics have been shown to improve H. pylori eradication rates and reduce side effects during treatment. Benefits of using probiotics as an adjunct treatment for H. pylori include: Increased eradication rate of H. pylori infection Reducing the side effects of antibiotics during treatment Restoration of gastric dysbiosis caused by eradication therapy.In a few preliminary studies, oral administrations of L. salivarius to H. pylori-infected gnotobiotic BALB/c mice showed a highly protective and therapeutic effect. Similarly, Coconnier etal۲۹ reported thatCONCLUSIONResearch has shown that some probiotic strains may help reduce H. pylori colonization and relieve symptoms. more research is needed to determine optimal strains, dosages, and treatment durations. Also, probiotics should not be used as the sole treatment for H.pylori, but rather as an adjuvant therapy to standard antibiotic therapy. Overall, although probiotics may play a role in the treatment of H. pylori infection more research is needed to determine their effectiveness as cures.

کلیدواژه ها:

Probiotics ، Helico bacter ، Eradication