Evaluation of bacteriophage efficacy in inhibiting methicillin-resistant Staphylococcus aureus isolated from patients with external ear infection in Vali-e-Asr Hospital in Fasa

BACKGROUND AND OBJECTIVESOtitis externa is a common inflammation in the external ear canal and eardrum. Otitis externa can be acute or chronic, with the acute form affecting four out of ۱,۰۰۰ people annually and the chronic form affecting ۳-۵% of the population. If left untreated, the acute disease can be followed by edema, discharge, pain, and finally, extra-canal manifestations. Due to the increase in the use of antibiotics in society, it is necessary to conduct various studies to control these bacterial agents in medical centers.MATERIALS AND METHODSIn this study, methicillin-resistant Staphylococcus aureus was isolated from patients with external ear infections in Fasa Wali Asr Hospital, its specific bacteriophages were isolated from the environment, and its antimicrobial properties were investigated.RESULTS AND DISCUSSIONThe results showed that the bacteriophages significantly reduces the number of bacterial colonies.CONCLUSIONThe obtained results showed that bacteriophages act specifically. Considering that the level of resistance to antibiotics is increasing, bacteriophages can be a suitable alternative to the use of antibiotics in the treatment of bacterial infections.

کلیدواژه ها:

Phage ، Phage Therapy ، Otitis Externa ، Antibiotic Resistance ، Methicillin-Resistant Staphylococcus Aureus.