Antimicrobial combinations against drug-resistant Acinetobacter baumannii: an in- vitro study

BACKGROUND AND OBJECTIVESThis study was aimed to explore effect of antimicrobial drugs combination against drug-resistant Acinetobacter baumannii.MATERIALS AND METHODSTwenty-four A. baumannii isolates were obtained from different clinical specimens included wounds, UTIs, sepsis and respiratory trac infections during ۲۰۲۲-۲۰۲۳, Tabriz, Iran. The resistance to antimicrobial agents were determined by the disk diffusion and microbroth dilution methods according to the CLSI guideline. Synergetic effects of the drugs combinations were determined using the checkerboard assay was used for fractional inhibitory concentration (FIC) index calculation.RESULTS AND DISCUSSIONThe highest synergic interaction was observed in colistin/imipenem and gentamicin/imipenem (۱۷ of ۲۴ isolates), and the lowest synergic interaction was observed in colistin/gentamicin and colistin/ciprofloxacin (۶ of ۲۰ isolates). Antagonist effects were not observed.CONCLUSIONDistinct and standard testing of inhibitory activity of the antimicrobial agent’s combination is required for treatment of high-level resistant pathogens. Colistin/imipenem and gentamicin/imipenem were more effective against carbapenem resistant A. baumannii.

کلیدواژه ها:

Acinetobacter baumannii ، Antimicrobial Combination ، resistant