The role of human microbiota in pulmonary tuberculosis

Globally, tuberculosis (TB) is not only a serious health issue but is also a major health concern caused by Mycobacterium tuberculosis. It is possible that individuals suffering from this disease are not being treated or perhaps are unaware that they are suffering from it. This may be due to the fact that the current treatment, diagnosis, and control strategies for TB may not be as effective as they could be. Dysbiosis of the normal microbiota, as well as epigenetic modifications appear to play a critical role in the pathogenesis of M. tuberculosis. While it may be fundamental, there is a lack of understanding about the role microbiota communities and epigenetic mechanisms play in TB infection. The development of experimental microbiota and epigenetics analysis for the purpose of developing innovative and effective TB infection control strategies appears to be a practical way to operate on microbiota and epigenetics analyses. There is also a need to understand how epigenetic mechanisms may be employed in order to design an effective TB control strategy. Therefore, the aim of current study is identifying the correlation between various microbiota communities and epigenetic mechanisms that occur upon TB infection. Such factors can represent a great opportunity for improving its control, while at the same time stressing the necessity for further research and evaluation.

کلیدواژه ها:

Epigenetics ، Microbiota ، Mycobacterium tuberculosis