Gastrointestinal microbiota as a double-edged sword for gastrointestinal cancer

BACKGROUND AND ABJECTIVEIn an attempt to determine the etiology of carcinogenesis and potential prognostic indicators, researchers have always been interested in the relationship between microorganisms and gastrointestinal (GI) carcinogenesis. There is ample evidence to suggest that the GI microbiota, specifically the pro-inflammatory and immunosuppressive signals it produces, contributes to the development of cancer.Microbiota profiles vary widely within and between populations, depending on factors such as age, diet, lifestyle, genetics, antibiotic use, and environmental factors. As a result, it is more appropriate to examine the GI tract microbiome in carcinogenesis. In the case of gastrointestinal cancers, examining the host's microbial profile may be necessary to gain important insight into the disease state. A better understanding of GI cancer and the host microbiota is necessary to gain important insights into the disease state.This review focuses on the role of the microbiota in the development of gastrointestinal cancers. We discuss how microbiota and their metabolites can increase the risk of cancer.MATERIALS AND METHODSNumerous databases were employed for this investigation, including Google Scholar, PubMed, EMBASE, and Scopus, each of which contained a large number of publications.Keywords like "Gut microbiome", "Gastrointestinal microbiota" and "Gastrointestinal cancer" were also utilized.RESULTS AND DISCUSSIONThe microbiota of the gastrointestinal tract, including the microbiota of the mouth, intestines, and stomach, through existing mechanisms, can predispose people to cancer or act as a cancer prevention factor. Just like a double-edged sword. Based on our findings, several intestinal bacteria such as Clostridium butyricum, Lactobacillus, Enterococcus faecalis, Bacteroides fragilis, and Bifidobacterium bifidum have therapeutic potential against gastrointestinal cancers using different mechanisms.CONCLUSIONConsidering the different roles of microbiota, both in causing cancer and in therapeutic potential, it is important to know more and better the microbiota of the gastrointestinal tract and their mechanism of action. Therefore, in this review, we try to know more about these factors.

کلیدواژه ها:

Gut microbiome ، Gastrointestinal microbiota ، Gastrointestinal cancer