Diet, Genetics and Probiotics: The Key Factors for a Healthy Gut Microbiome

BACKGROUND AND ABJECTIVEIn this study we explain that the gut microbiome is the genetic material of the microorganisms that live in the human digestive system and that dysbiosis, or an imbalance of gut bacteria, has been shown to be closely associated with certain diseases and condition.MATERIALS AND METHODSThis study is based on a literature search and analysis of the existing studies on how diet, genetics, and personalized approaches for probiotics affect the microbiome and its detoxification capacity. The articles were identified from English databases using keywords.RESULTS AND DISCUSSIONThe microbiota and the anti-inflammatory molecules produced by bacteria can be affected by diet. Consuming fiber, protein, fat, polyphenols, tryptophan, and probiotics, prebiotics and supplements can modification these molecules. The gut microbiome composition can be affected by genetics, which determine which microbes can live and grow in the gut and how they interact with the host factors. Different genetic variants can affect the intestinal mucosal barrier, the immune response, and the drug and food metabolism of the host, which in turn can affect the availability of nutrients, oxygen, and other factors for the microbes. Some genetic variants can also affect the susceptibility and response to certain diseases or conditions that are related to these microorganisms. Different genetic variants and the gut microbiome interact and affect each other like LCT-MCM۶ (Bifidobacterium and lactose), ABO-FUT۲ (Faecalicatena lactaris and blood antigens), MED۱۳L (Enterococcus faecalis), NOD۲ (Roseburia, Eubacterium rectale and butyrate), TNFSF۱۵ (Ruminococcus gnavus and IBD), SLC۲۳A۱ (Akkermansia muciniphila, mucin, obesity and metabolic syndrome).Personalized approaches for probiotics aim to identify the most suitable probiotic strains and doses for each individual, based on their specific characteristics and goals. Using microbiome data, host data, feedback data such as self-reporting can help to optimize the benefits of probiotics for detoxification by reducing the variability and uncertainty of the probiotic effects.CONCLUSIONDiet, genetics, and personalized approaches for probiotics can affect the metabolism and balance of the microbiome and its detoxification capacity and prevent negative consequences for our nutrition genetics, and disease. Therefore, it is necessary to understand how these factors influence the microbiome and how to modulate it for optimal detoxification.

کلیدواژه ها:

Dysbiosis ، Microbiota ، Probiotics ، Fermented Foods ، Genetic