Nanofilms as antimicrobial protection in medical industry

BACKGROUND AND OBJECTIVESBiomaterials are recently considerable in antimicrobial activities or the treatment of infections. Nanofilms are a tape-like gathering of nanomaterials, which could have antimicrobial, anti-biofilm, anti-inflammatory and pro-angiogenesis activities by inhibiting the adherence of bacteria to surfaces including tissues and medical devices. These biomaterials could also have drug delivery performances as like as antibiotic delivery to infected organs. In this study, we aim to review the activities of nanofilms in preventing or the treatment of infections in last decade.MATERIALS AND METHODSGoogle scholar and Pubmed were explored by the collection of ۱۰ keywords according to Medical Subject Headings (MeSH). The search results were limited to the last ۱۰ years (from ۲۰۱۳ to ۲۰۲۳) and lastly, all the relative articles were collected and reviewed.RESULTS AND DISCUSSIONInvestigated medical nanofilms were mainly made of chitosan, chlorhexidine, titanium oxide, poly-L-lactic acid, cooper, silver, carboxymethyl cellulose and iron-silver-tannic acid. Their applications are described as a protection in preventing of some infectious diseases such as wound infections, and also antibiotic drug deliveries. They could be used in sealing of invasive medical devices such as catheters, surgical devices and surgical sutures. Also, covering of hospital setting by antimicrobial nanofilms could prevent the hospital-acquired infections in hospitalized patients.CONCLUSIONNanomaterials including nanofilms are suitable agents in preventing or treating the infections with stable materials. They are also useful for drug or antibiotic deliveries in infected patients. It is recommended the investigations on the impact of nanofilms on the microbial involvement in other medical and surgical devices such as artificial heart valves and endotracheal, endoscopy or colonoscopy tubes, to be accurately carried out.

کلیدواژه ها:

Nanofilms ، Nanomaterials ، Nanotechnology ، Infections ، Anti-infective agents