Inhibitory effects of cell extract from Lactobacillus species on K۵۶۲ cell lines

BACKGROUND AND ABJECTIVELeukemia, a malignancy affecting the hematopoietic cells, has a high mortality rate in individuals under ۲۰ years old. Resistance to chemotherapy has led to the expansion of research based on alternative treatment. Studies indicated that certain bacterial proteins and short peptides possess inhibitory properties against various tumor cells. The purpose of a literature review is to research on the beneficial effects of probiotics on the K۵۶۲ cell line, which consists of myeloid-derived blood cancer cells.MATERIALS AND METHODSThis review, analyze the studies conducted between ۲۰۱۱ and ۲۰۲۳, focusing the impact of various types of Lactobacillus species on the K۵۶۲ cell line. scientific databases such as Google Scholar, Scopus, PubMed, and SID were selected for this review.RESULTS AND CONCLUSIONThe results of this review indicated that the cell wall and cytoplasmic extract of Lactobacillus casei, paracasei, and reuteri have significant cytotoxicity against K۵۶۲ myeloid cancer cells. The cell wall protein fractions derived from different Lactobacillus strains inhibit K۵۶۲ cancer cell growth and protein fractions with higher molecular weight notably exhibit greater anticancer effects. The survival rate of cancer cells was related to the concentration and duration of exposure to lactobacilli-derived cell extracts. Moreover, the specific beneficial effects of these bacteria in inhibiting cancer cell growth may be vary between different Lactobacillus species. The mutated p۵۳ gene, (tumor suppressor), contribute to cancer development. Heightened expression of mutated p۵۳ proteins enhances resistance to apoptosis. Thereby, the cytoplasmic extract and cell wall of Lactobacillus induce apoptosis in K۵۶۲ cells by reducing mutated p۵۳ protein levels.The extract obtained from Lactobacillus bacteria can be utilized as a component of a pharmaceutical formulation for the effective treatment of myeloid leukemia.

کلیدواژه ها:

K۵۶۲ Cell Line ، Lactobacillus Species ، Cancer Therapy