Detection of Biologically Active Compounds in Eriobotrya japonica L. Seeds Extract and Determination of Their Effectiveness Against Dermatophytes

The antifungal activity of Eriobotrya japonica L. seeds extract obtained from Baghdad was evaluated against nine clinical fungi isolates of dermatopytes (T. rubrum, T. mentographytes, M. canis, T. verrucosum, T. quinckeanum, Epidermophyton, T. simii, T. interdigitale and Fusarium). The results presented in this work demonstrated that the seeds extract showed a significant effect against dermatophytes at ۳۰۰ mg/ml concentration, with percentage inhibition growth ranging from ۱۰۰% to ۹۶.۵۶%, compared to concentrations at ۱۵۰ and ۷۵ mg/ml, with percentage inhibition growth ranging from ۹۷.۲۷% to ۸۶.۶۶% and from ۹۳.۶۶% to ۷۹.۸۴% respectively. The end results of GC-MS analysis indicated that the ethanol seeds extract of loquat have a lot of active chemical compounds, including twenty-five phytoconstituent compounds, that are distinguished in the extract of seeds with E. japonica L. In addition, the high area % revealed in each extracts were: Propylene glycol monooleate ۵.۰۳%, D-Mannitol or DL-Glucitol ۵.۶۷%, Beta-sitosterol ۵.۷۰%, n-Hexadecanoic acid ۱۴.۵۳% and ۹,۱۲-Octadecadienoic acid (Z,Z)- ۲۲.۸۵%.

کلیدواژه ها:

Eriobotrya japonica ، Seeds ، Dermatopytes ، Ethanol extract ، Antifungal