Cytotoxic properties (MDA-MB-۲۳۱- an epithelial breast cancer cell line) and bactericidal activity of Silver nanoparticles mediated by Strobilanthes ciliata nees

The sciences that intrigue about nanotechnology are increased ever before and improved permeability in its applications at various arenas. Precisely, the Silver nanoparticles (AgNPs) implication is deep-time perspective to understand that fascinating nanomaterials are involved in different biomedical applications. Since NPs application derivates are physical and chemical based but biological methods is still holds a profound impact. Hence, the medicinal plant Strobilanthes ciliata was utilized to synthesis AgNPs and the same was subjected to UV irradiation. And subsequent application of the crude biosynthesis of AgNPs was experimented with various physico-chemical parameters. Biosynthesized particle characterization was carried out by color pattern and UV-visible spectroscopy and followed by FTIR, SEM and finally experimenting with cancer cells as cyto-toxic study. The characterization result of particle size of synthesized AgNPs is ۷۷ nm. The highest peak obtained in FTIR is at ۳۴۳۹.۴۸cm−۱ (OH) and the UV range is ۴۷۷ nm. As far as the cancer cells are concerned, the cell survival rate at ۱ mcg is ۶۲% and at ۱.۵ mcg is ۳۰% which is optimal. The lattice planes of XRD are face-centered-cubic (FCC) structure. The Particle size of S.ciliata mediated AgNPs is ۷۷.۷ nm. Biological methods attain much concern and forethought because bio-resources are used as precursors in synthesis of NPs. Therefore, herein we exclusively have done the plant-mediated metallic NPs synthesis, characterization and applications in detailed summary.  The present research observation will hold enrich understanding about AgNPs interaction and the mode of synthesis with various expertise and subject.

کلیدواژه ها:

Cancer cells ، Characterization ، green chemistry ، Nanomaterials ، Strobilanthes Ciliata