Expression of Estrogen Receptor (ER), Progesterone Receptor (PR), Her۲/neu in Various Types of Epithelial Ovarian Tumors

Introduction:The highest mortality rate in gynecologic cancers is attributed to ovarian origin. Expression of the estrogen and progesterone receptors (ER and PR); and Human epidermal growth factor receptor ۲ (Her۲/neu) in endometrial cancer and breast cancer were found to be associated with the response to treatment and prognosis. However, because of inconsistent results from previous studies, the data regarding ovarian cancer are still inconclusive.Materials and methods: Current retrospective cross-sectional study was performed on ۲۳۴ tissue samples of different types of ovarian tumors (benign, borderline and malignant) from the archive of the University Kebangsaan Malaysia Medical Center during ۱۰ years. Tissue microarrays were constructed on representative areas from formalin fixed paraffin embedded tissue blocks using ER, PR and HER۲ immunohistochemical staining. Results: Prevalence of ER and PR overexpression was ۳۶% and ۳۵% in benign, ۸% and ۲۴% in borderline tumors with ۵۱% and ۴۶% in malignant tumors, respectively. ERα overexpression was more common among serous malignant ovarian tumors (۴۹%) (p<۰.۰۰۱). PR positivity was more prevalent in serous benign tumors (p=۰.۰۲).There was no significant relationship between stage and the status of ERα (p=۰.۱۲) and PR (p=۰.۱۹). Her۲/neu overexpression was only seen in borderline neoplasms (۸%) and malignant mucinous tumors (۴%). No association was found between Her۲/neu overexpression and the level of tumor differentiation, tumor stage, size, and patient’s age.Conclusion: The observed ERα positivity in serous carcinoma and Her۲/neu overexpression in malignant mucinous tumor, could be considered as a clue for choosing therapeutic agents. The role of anti-HER۲ therapy in clear cell carcinoma is still debated and needs more investigations.

کلیدواژه ها:

Ovary ، Müllerian ، Er ، PR ، HER۲/neu ، Immunohistochemistry