Pharmaceutical, nutritional, and cosmetic potentials of saponins and their derivatives

Saponins as glycoside type of pentacyclic triterpenoids comprising an aglycone (triterpenoid component) and glycone (sugar moiety) are acknowledged phytochemicals with various pharmaceutical and nutritional activities as natural additives in food and cosmetic sections. These amphiphilic molecules and their derivatives have shown numerous therapeutic and nutritional benefits. Antioxidant, anticancer, hypoglycaemic, hypolipidemic, anti-asthmatic, and antimicrobial effects have been found for saponins and their derivatives such as furostanol saponin as the main therapeutic potential along with low cytotoxicity. In the case of the nanotechnology aspect, these emulsifiers are significantly employed to stabilize and produce nanoemulsions. However, the bioavailability and stability of these glycoside metabolites are affected by the processing method owing to the changes between the linkages of glycone chains and aglycones. Organic nanomaterials such as lipidic and polymeric nanomaterials may be promising nanocarriers for increasing the bioavailability and stability of saponins, we have reviewed recent findings about this issue focusing on cosmetic, nutritional, and pharmaceutical potentials.

کلیدواژه ها:

Pentacyclic triterpenoids ، Hypoglycaemic ، Hypolipidemic ، Anti-asthmatic ، Cosmetic potential ، Furostanol saponin ، Nanotechnology aspect ، Nanoemulsion