Prevalence and Antibiotic Susceptibility Profile of Methicillin-Resistant Staphylococcus aureus (MRSA) Isolates in Diabetes Patients with Foot Ulcers

Introduction: methicillin-resistant Staphylococcus aureus (MRSA) infection is common among diabetes patients with foot ulcers. This study aimed to determine MRSA isolates prevalence and antibiotic susceptibility profile in diabetic foot ulcers (DFU) patients. Methods: A total of ۲۰۴ patients with diabetic foot ulcers admitted to a tertiary hospital in Abia State, Nigeria, were included in the assay. Specimens were obtained by scraping the ulcer base or the deep portion of the wound edge using a sterile curette and were promptly sent to the laboratory for culture, identification, and antibiotic susceptibility test.  Results: The MRSA prevalence in DFU patients was ۲۲.۱% (n=۴۵). Male patients with DFU were more infected with MRSA (n= ۲۶, ۱۲.۷%) than females (n=۱۹, ۹.۳ %), but the difference was not statistically significant (P < ۰.۱۴). The age group ۴۱-۶۰ years had the highest prevalence (n=۲۷, ۱۳.۲%), statistically significant (P < ۰.۰۲). Farmers had the highest prevalence of ۹.۸% (n=۲۰) while the least (۰.۵%) was seen in housewives (n=۱) with no statistical significance (P < ۰.۰۷). The antibiotics sensitivity pattern of MRSA showed ۱۰۰% sensitivity to vancomycin and chloramphenicol but ۱۰۰% resistance to penicillin, ceftriaxone, and oxacillin. The multidrug-resistant index was all > ۰.۲. Conclusions: The prevalence of MRSA in DFU patients in a tertiary hospital in Abia State was very high, with an alarming rate of drug-resistant bacteria due to the possibility of misuse and abuse of antibiotics among the populace, which requires collaborations from all stakeholders to prevent drug resistance in the study settings.

کلیدواژه ها:

Methicillin-resistant staphylococcus aureus ، Diabetic foot ulcers ، Abia State ، Nigeria