Parameters of Coagulation in COVID-۱۹ Patients: A Correlation with Clinical Severity

Introduction: COVID-۱۹ infection can be complicated by coagulation derangement and a high risk of thromboembolic episodes. Our study aimed to investigate coagulation parameters in COVID-۱۹ patients and their correlation with clinical severity. Methods: We analyzed coagulation parameters PT, APTT, D-Dimer, and Fibrinogen in ۹۸ RT-PCR-confirmed COVID-۱۹ patients admitted to the Government Institute of Medical Sciences, Gautam Buddha Nagar, Uttar Pradesh, India. Results: This study involved ۶۹ males (۷۰.۵۰%), and ۲۹ (۲۹.۵%) were females. The mortality rate was ۶.۱۲% (n= ۰۶). Forty-six patients (۴۶.۹۴%) had comorbidities. Thirty-four patients had elevated PT, and ۷ had high APTT, whereas D-dimer and fibrinogen levels were raised in ۶۸ and ۶۱ patients, respectively. Among all four parameters, D-Dimer levels were significantly associated with disease severity. Conclusion: Derangement of D-dimer levels is significantly associated with disease severity in COVID-۱۹ infection.

کلیدواژه ها:

APTT ، Coagulation ، D-Dimer ، Fibrinogen ، PT ، COVID-۱۹