Evaluation of Serum Interleukin-۱۷, Transforming Growth Factor-beta Levels in Brucellosis Patients Before and After Treatment

سال انتشار: 1401
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 41

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شناسه ملی سند علمی:

JR_JMMI-10-4_007

تاریخ نمایه سازی: 29 بهمن 1402

چکیده مقاله:

Introduction: Brucellosis is a zoonotic disease in humans and animals and is a worldwide public health problem. Changes in inflammatory cytokines levels might be deployed as markers for diagnosing infectious diseases from non-infectious medical conditions. This study aimed to evaluate the relationship between serum levels of interleukin-۱۷ (IL-۱۷) and transforming growth factor-beta (TGF-β) in pediatric brucellosis. Methods: The present case-control study included ۴۰ brucellosis patients and ۴۰ matched healthy controls. Serum levels of inflammatory cytokines were measured by ELISA, and the independent student t-test was used to compare the levels in the brucellosis and healthy group. Serum cytokine levels before and after treatment were compared by the paired samples t-test. Results: The serum TGF-β level was significantly lower in the patients compared to the control group (۹۰.۲۱ ± ۲۴.۴۴ vs. ۱۲۵.۶۳ ± ۲۳.۲۸ pg/mL, P<۰.nv۰۰۱), and the serum interleukin-۱۷ level was significantly higher in the case group (۸۳.۷۴ ± ۲۳.۵۷ vs. ۲۵.۹۵ ± ۱۷.۸۰ pg/ml, P<۰.۰۰۱). After treatment, serum IL-۱۷ levels significantly decreased in the case group. Conclusion: In brucellosis patients, the serum IL-۱۷ levels decreased significantly, whereas TGF-β increased significantly in these patients. Hence, the serum levels of these inflammatory cytokines can be indicators for diagnosing pediatric brucellosis.

نویسندگان

Roozbeh Esalatmanesh

Medical Student, Kashan University of Medical Sciences, Kashan, Iran

Mohammad Reza Sharif

Infections Diseases Research Center, Kashan University of Medical Sciences, Kashan, Iran

Kamal Esalatmanesh

Department of Rheumatology, Kashan University of Medical Sciences, Kashan, Iran

Shirin Heidari

Medical Student, Kashan University of Medical Sciences, Kashan, Iran

Zahra Soleimani

Infections Diseases Research Center, Kashan University of Medical Sciences, Kashan, Iran

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