Primary Multidrug-Resistant Mycobacterium Tuberculosis (P-MDRTB) in Gorgan, Iran

Background: Resistance to anti-tuberculosis (TB) drugs is a global problem. Previous studies showed that the prevalence of primary MDR-TB is higher and has been increasing. The purpose of this study was to determine the primary drug resistance in strains isolated from patients with smear-positive of the new cases to anti-TB drugs.Methods: In this cross-sectional study, ۲۶۶ smear positive pulmonary TB Iranian patients were enrolled during the April ۲۰۱۱ and March ۲۰۱۲. Drug Susceptibility Testing (DST) of M. tuberculosis isolates to the first-line drugs, isoniazid, rifampicin, ethambutol, and streptomycin, were performed by the proportion method using conventional Lowenstein-Jensen (L-J) medium.Results: The average age was ۴۸.۴ ± ۲۱.۳ years, and ۵۶.۵ percent were male. In this study, out of ۲۶۶ pulmonary TB suspects studied, susceptibility testing was performed for ۱۸۹ isolates. Resistance to at least one drug was present in ۱۱.۱% (۲۱/۱۸۹) of cases. Resistance among newly diagnosed patients was most common for streptomycin, and MDR prevalence rates (resistant to ISONIAZID and RIFAMPIN) among these patients were ۲.۱%.Conclusions: Our finding suggests that the incidence of MDR tuberculosis in high TB burden settings stresses the need for drug susceptibility testing to be done for every patient who is culture positive for Mycobacterium tuberculosis.Background: Resistance to anti-tuberculosis (TB) drugs is a global problem. Previous studies showed that the prevalence of primary MDR-TB is higher and has been increasing. The purpose of this study was to determine the primary drug resistance in strains isolated from patients with smear-positive of the new cases to anti-TB drugs. Methods: In this cross-sectional study, ۲۶۶ smear positive pulmonary TB Iranian patients were enrolled during the April ۲۰۱۱ and March ۲۰۱۲. Drug Susceptibility Testing (DST) of M. tuberculosis isolates to the first-line drugs, isoniazid, rifampicin, ethambutol, and streptomycin, were performed by the proportion method using conventional Lowenstein-Jensen (L-J) medium. Results: The average age was ۴۸.۴ ± ۲۱.۳ years, and ۵۶.۵ percent were male. In this study, out of ۲۶۶ pulmonary TB suspects studied, susceptibility testing was performed for ۱۸۹ isolates. Resistance to at least one drug was present in ۱۱.۱% (۲۱/۱۸۹) of cases. Resistance among newly diagnosed patients was most common for streptomycin, and MDR prevalence rates (resistant to ISONIAZID and RIFAMPIN) among these patients were ۲.۱%. Conclusions: Our finding suggests that the incidence of MDR tuberculosis in high TB burden settings stresses the need for drug susceptibility testing to be done for every patient who is culture positive for Mycobacterium tuberculosis.

کلیدواژه ها:

Mycobacterium infections ، Tuberculosis ، Gram-positive bacterial infections ، Multidrug-resistant tuberculosis.