Background: Tramadol is a drug used to control severe pain. Various side effects of this drug have been reported, one of the most important is seizures. The exact cause of tramadol-induced seizures is not known. The aim of this study was to investigate the effect of tramadol addiction on convulsion and related factors in ۲۰۱۸.Methods: This cross-sectional study was performed on ۲۱۶ patients with convulsion referred to Imam Hossain Hospital of Shahroud in ۲۰۱۸. After reviewing and stabilizing vital signs, a questionnaire containing demographic information, medical history, medication use (especially tramadol), and drugs was completed by patients. The association between recurrent convulsion and predictors were assessed using multivariable logistic regression. Data were analyzed and compared using SPSS statistical software, version ۱۶ and related statistical tests. The significant level was set at ۰.۰۵.Results: In this study from ۲۱۶ participants, ۱۵۴ (۷۱.۳%) of them were male and the rest were female. The mean age of the all patients was ۴۴.۸±۱۸.۲ years (۱۷-۷۲ years) that was no significant difference between the two groups. Recurrent convulsion was significantly associated with history of opium use (Pvalue<۰.۰۳۲) and tramadol using (Pvalue<۰.۰۰۱) and there was no significant relationship with other variables. Tramadol using cans double your chances of having a recurrent convulsion [OR=۲ (۹۵% CI: ۱.۷۵۲ – ۲.۶۸۹)].Conclusions: The results of this study showed that taking tramadol in opium users can increase the incidence of recurrent convulsion, but more research is needed to fully confirm this.Key words: Tramadol, Convulsion, Side effectsBackground: Tramadol is a drug used to control severe pain. Various side effects of this drug have been reported, one of the most important is seizures. The exact cause of tramadol-induced seizures is not known. The aim of this study was to investigate the effect of tramadol addiction on convulsion and related factors in ۲۰۱۸. Methods: This cross-sectional study was performed on ۲۱۶ patients with convulsion referred to Imam Hossain Hospital of Shahroud in ۲۰۱۸. After reviewing and stabilizing vital signs, a questionnaire containing demographic information, medical history, medication use (especially tramadol), and drugs was completed by patients. The association between recurrent convulsion and predictors were assessed using multivariable logistic regression. Data were analyzed and compared using SPSS statistical software, version ۱۶ and related statistical tests. The significant level was set at ۰.۰۵. Results: In this study from ۲۱۶ participants, ۱۵۴ (۷۱.۳%) of them were male and the rest were female. The mean age of the all patients was ۴۴.۸±۱۸.۲ years (۱۷-۷۲ years) that was no significant difference between the two groups. Recurrent convulsion was significantly associated with history of opium use (Pvalue<۰.۰۳۲) and tramadol using (Pvalue<۰.۰۰۱) and there was no significant relationship with other variables. Tramadol using cans double your chances of having a recurrent convulsion [OR=۲ (۹۵% CI: ۱.۷۵۲ – ۲.۶۸۹)]. Conclusions: The results of this study showed that taking tramadol in opium users can increase the incidence of recurrent convulsion, but more research is needed to fully confirm this. Key words: Tramadol, Convulsion, Side effects