Influence of glutamine supplementation on muscle damage and oxidative stress indices following ۱۴km running

Introduction: The aim of this study was to evaluate effects of ۷ day glutamine supplementation on exercise-induced oxidative stress and muscle damage. Methods: Nineteen healthy, nonsmoking, young men were recruited to participate in this study. Participants were randomized in a double-blind placebo-controlled fashion into ۲ groups: Glutamine (G group) (n=۹) and placebo (P group) (n=۱۰). Subjects consumed daily either glutamine (۱.۵ g/kg glutamine+۲۵۰ml water+۱۵g sweetener) or placebo (۲۵۰ml water+۱۵g sweetener) for ۷days. Then, participants ran ۱۴km and were allowed to consume water throughout the exercise. Blood samples were taken before supplementation, before exercise, immediately, and ۱h after exercise. Results: Creatine kinase (CK) significantly increased in both groups after exercise compared with pre-exercise (P<۰.۰۵). Moreover, there was a significant CK increase in P group compared with the G group ۱h after exercise (P=۰.۰۲۱). TAC significantly increased immediately post-exercise compared with pre-exercise just in the G group (P<۰.۰۵). There was significant reduced glutathione (GSH) increase in the G group after supplementation, immediately, and ۱h after exercise, but just ۱h after exercise in P group compared with baseline (P<۰.۰۵). Malondealdehyde (MDA) significantly increased ۱h after exercise compared with pre-exercise just in P group (P<۰.۰۵). There was any within or between groups’ differences in serum total bilirubin (P>۰.۰۵). Conclusion: It seems ۷ day glutamine supplementation has been able to affect oxidative stress and muscle damage markers via possibly an effect on antioxidant agents.

کلیدواژه ها:

Glutamine ، Muscle Damage ، Creatine Kinase (CK) ، Glutamine ، Muscle Damage ، Creatine Kinase (CK)