Screening of antibacterial effect of the Scrophularia Striata against E. coli in vitro

Introduction: This study was aimed to evaluate the antimicrobial activity of the ethanol and aqueous extracts of Scrophularia striata plant on E. coli O۱۵۷:H۷ in vitro. Methods: In this experimental study the ethanol and aqueous extract of the plant was prepared and their antibacterial effects were determined using sink diffusion and broth macrodilution methods against the bacterium E. coli O۱۵۷:H۷. Results: The ethanol extract of Scrophularia striata plant had inhibitory effect on the E. coli O۱۵۷:H۷ in two methods of sink diffusion and macrodilution, but the aqueous extract of this plant had not antibacterial effect. The MIC and MBC amounts were obtained ۹۰mg/ml and ۱۰۰ mg/ml, respectively. Conclusion: Based on the present results that the ethanol extract of the Scrophularia Striata plant showed inhibitory effect on bacterium, more researches are recommended to evaluate its in vivo effects and to identify active compounds.