The effect of silymarin on non-alcoholic fatty liver disease of children

Introduction: Non-alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases of adults and its prevalence is increasing in children and adolescents. It is the most predisposing factor for liver cirrhosis. Due to complications of NAFLD, the treatment of this disease is essential. Since silymarin is recommended for adults recently, the effect of this herbal drug on children and adolescents was evaluated for treatment of NAFLD in children.Methods: This is a clinical trial study, which was done in Shahrekord University of Medical Science in ۲۰۱۲-۲۰۱۳ on ۵-۱۶ years old children with NAFLD. The patients were randomly divided into two groups containing ۲۰ patients in each group. Silymarin tablets were administered for ۱۲ weeks in case group and changing life style including exercise was advised in both groups. Liver sonographay and liver function tests (LFTs) were done after ۱۲ weeks.Results: Patients with higher grade of fatty liver were developed lower grade of fatty liver during intervention in case group based on sonography after ۱۲ weeks (P = ۰.۰۰۱). Meanwhile, no significant changes were observed in control group (P = ۰.۳۵). Liver enzymes (alanine aminotransferase [ALT] and aspartate transaminase [AST]) (P = ۰.۰۰۱, P = ۰.۰۲۵, respectively) and triglyceride (TG) levels (P = ۰.۰۴۳) were improved significantly but low-density lipoprotein (LDL) and high-density lipoprotein (HDL) did not change during intervention in case group.Conclusion: Silymarin can improve fatty infiltration of liver and liver function in children and adolescents.