Review the Association of Ala۵۱۳Pro and Gly۹۷۲Arg IRS-۱ Gene Polymorphism with Gestational Diabetes Mellitus in South of Iran

Introduction: Gestational diabetes mellitus is a multi-factor disease. Several genes are shown to be associated with diabetes mellitus. Among them, IRS-۱ gene is located on chromosome No.۲ which is an endogen substrate for insulin receptor. IRS-۱ gene has an important role in insulin pathway signaling. Aim of this study was to review the association of Ala۵۱۳Pro and Gly۹۷۲Arg IRS-۱ gene polymorphism with gestational diabetes mellitus in south of Iran. Methods: ۲۰۰ subjects with gestational diabetes mellitus and ۲۰۰ healthy subjects as control group were enrolled in the study. DNA was extracted from their blood and polymorphism of G, C and T allele were studied. It was aimed to investigate whether genotype is associated with clinical and biochemical variables such as family history, fasting blood sugar, blood lipid and body mass index. Independent sample t- test, chi- square test, logistic regression and Hardy- Weinberg equilibrium tests were used to analyze data (p≤۰.۰۵). Results: The finding from the Polymorphism Gly۹۷۲Arg study show that individuals with CC, CT genotypes were associated with an increased risk of the disease (%۹۵CI: ۰.۰۲-۰.۴۴, OR=۰.۱, P<۰.۰۰۱), (%۹۵CI:۲-۵۸.۴۳, OR=۹.۲, P<۰.۰۱). There was no allele and genotypic variation in Polymorphism Ala۵۱۳Pro Polymorphism. Conclusion: Based on the obtained results, Ala ۵۱۳Pro polymorphism of the IRS-۱ gene was not correlated, but Gly ۹۷۲ Arg polymorphism related with gestational diabetes mellitus in population of south Iran.

کلیدواژه ها:

Gestational Diabetes ، Polymorphism ، Iran