Investigation of megaloblastic anemia and treatment with cobalaminsupplementation

Megaloblastic anemia (MA) encompasses a heterogeneous group of macrocytic anemias characterized by thepresence of large red blood cell precursors called megaloblasts in the bone marrow. This condition is due toimpaired DNA synthesis, which inhibits nuclear division. Megaloblastic anemia is most often due tohitaminosis, specifically vitamin B۱۲ (cobalamin) and folate deficiencies, which are necessary for the synthesisof DNA. In rare cases, MA is due to inherited problems and it can increases with age.Reviewing CBC test shows that when the hematocrit falls <۲۰%, megaloblasts may appear in the blood andthe neutrophils which typically show hypersegmentation of their nuclei, beyond the usual ۳ to ۵ lobes, maycontain ۶ or more lobes.

کلیدواژه ها:

Megaloblastic anemia- cobalamin-tesetCCBC