Evaluation of Amikacin and Gentamicin Resistant Production in Klebsiella Pneumoniae in Iraq

Background: Klebsiella pneumoniae (K. pneumoniae) can cause ventilator- associated pneumonia, urinary tractinfection, sepsis, catheter- related infection, and bacterial meningitis, and is also the most common causativegram-negative bacterium in nosocomial and community- acquired infections. In recent years, this bacterium hasacquired high resistance to broad-spectrum antibiotics such as β lactams, aminoglycosides, and quinolones. Thepresent study, aimed: to detect Klebsiella pneumonia in different clinical specimens and detect theirAminoglycoside Antibiotic Group resistance profile. Methods: A total of ۱۴۵ clinical specimens including sputum,blood, urine, burn, wound and stool swabs were obtained from both genders and different ages. The sampleswere streaked on the blood and MacConkey agars and the bacterial growth identified by using biochemical testsand the Vitek®۲ system to confirm it. The antibiotic susceptibility test was performed with the use of anantibiotic susceptibility kit card (Vitek® ۲ AST Reference number ۴۱۳۰۸۳, bioMe rieux, France). Results: Out of۱۴۵ clinical samples, K. pneumonia was recorded in ۷۰ (۴۸.۲۷%) cases. The highest isolation rate of Klebsiellapneumonia was in urine ۳۰(۴۳%), followed by blood ۱۲(۱۷%) and sputum ۱۷ isolate (۲۴%), stool ۴(۶%), woundand burn swab ۵(۷%) and the least isolation was in CSF with two isolate (۳%). Furthermore, females were moreaffected ۴۵ (۶۴%) with K. pneumonia than males ۲۵ (۳۶%) and most infected patients were with age group ≥۳۰Amikacin than gentamicin. years. The results revealed that Klebsiella pneumonia isolates were highly resistant toConclusion: Klebsiella pneumonia may be consider as risk factor for urinary tract infection and females have agreater chance of developing Klebsiella pneumonia infection, and it is important to monitor the circulation of K.pneumoniae resistant to the Aminoglycoside Antibiotic Group to prevent the spread of clones causing difficult to-treat infections.

کلیدواژه ها:

Klebsiella pneumonia ، antibiotic resistance