Investigating the Effect of Propolis Mouthwash in the Treatment of Mucositis Caused by Chemotherapy

ed oral mucositis is regarded as a painful and discomforting chemotherapy complication , affecting patient's quality of life and endurance to continue the treatment. Hence, treatment of mucositis is of great significance. The present study was conducted to evaluate the effect of Baremoom mouthwash in treatment of chemotherapy-induced mucositis.Methods: This interventional double-blinded randomized clinical trial study was performed on ۴۰ adult patients under chemotherapy in blood and oncology department of Shahid Sadouqhi hospital. The total of ۴۰ patients were randomly divided into two groups: an experimental baremoom group and a control placebo group each containing ۲۰ subjects. Baremoom mouthwash (۳۰% extract, Soren Tektoos, Mashhad) and placebo mouthwash ( Sterile water with allowable additives ,Soren Tektoos, Mashhad ) with same apparent properties were given to the patients (۳ times a day) for ۷ days after mucositis detection. The patients were evaluated in regard with mucositis grade (۰-۴ WHO) and wounds extension on ۱th , ۳th and ۷th days after the study begining. In order to statistically analyze the collected data, Freidman, Mann–Whitney, and wilcoxon W tests were applied utilizing SPSS software (ver, ۱۷).Results: On ۳rd and ۷th days, mean degree of wound extension and mucositis were demonstrated to be significantly different between the two groups. According to Friedman test, both experimental and control groups revealed a significant difference in regard with wound extension and mucositis grade within the three time periods.Conclusion: The study findings indicated that Baremoom mouthwash was more effective in chemotherapyinduced mucositis than placebo. Hence, this agent can be recommended as an appropriate medicine in order to eliminate mucositis symtoms and decrease oral ulcers

کلیدواژه ها:

Baremoom ، Chemotherapy ، Mucositis ، Propolis