Drug-loaded electrospun fibers have attracted increasing attention as a promising wound dressing material due to their capability of preventing from infections and inflammation and maintaining an appropriate environment for wound healing. polylactic acid (PLA) and
Hyaluronic acid (HA), which is widely used in wound management, was chosen as electrospinnable polymer.
Hyaluronic acid (HA) is a main constituent of the extracellular matrix (ECM) of a vertebrate’s connective tissue, represents a promising biomaterial for wound dressing thanks to its intrinsic biocompatibility, hydrophilicity and bacteriostatic properties.The wound healing ability of PLA/H.a-based electrospun nanofibers loaded with niacinamide is explored.Niacinamide known for its anti-inflammatory,Improve angiogenesis and wound healing effects was chosen to produce niacinamide loaded PLA/H.A electrospun fibers for wound dressing.morphology of niacinamide loaded PLA/H.A electrospun fibers was investigated by scanning electron microscopy (SEM). SEM images showed that PLA/H.a-based electrospun nanofibers loaded with niacinamide possessed a denser network with smaller pores than PLA or H.a which prevents bacterial penetration.In vitro release studies showed that PLA/H.a membrane in a Fickian diffusion manner, whose experimental data were well fitted using the Korsmeyer-Peppas model. Moreover, culturing experiments with human dermal fibroblast (HDF) cells demonstrated that all samples are biocompatible and showed that the niacinamide loaded PLA/H.A nanofibrous membranes support better cell attachment and proliferation compared to the PLA/H.A nanofibrous membranes, owing to the superior hydrophilicity.In conclusion, the design and development of PLA/H.a-based electrospun nanofibers as a wound dressing can be improved by the addition of loaded with niacinamide to obtain the fibers with optimal properties for wound management.