Silver Nanoparticles and Their Effect on Wound Healing

Wounds provide a suitable environment for the growth of harmful bacteria, and the increasing bacterial resistance to existing antibiotics necessitates the exploration of new approaches in the medical field. Scutellaria barbata, a perennial herb widely employed in traditional Chinese medicine for its anti-inflammatory, anti-infective, and detoxifying properties, has garnered significant attention. Silver nanoparticles derived from Scutellaria barbata aqueous extract exhibit remarkable efficacy as a wound healing agent. Silver nanoparticles (AgNPs) produced through the biosynthesis method involving the probiotic bacteria Lactiplantibacillus plantarum exhibited enhanced antimicrobial activity against wound infection-causing pathogens and displayed effective in vitro wound-healing properties. While AgNPs have been explored for their antimicrobial properties, their limited ability to penetrate biofilms have remained areas of research interest. The incorporation of IONPs into the bionanocomposites demonstrated a synergistic enhancement of antibacterial and antibiofilm properties. Application of an external magnetic field (EMF) to IONP-loaded bionanocomposites resulted in significant AgNPs release. This controlled release significantly boosted antibacterial activity and effectively inhibited biofilm formation. Moreover, AgNPs have the potential to combat antibiotic-resistant bacterial biofilms, and its characterization and mechanism of action are described that offers new perspective on addressing bacterial infections by targeting biofilms with various nanocomposites.Methods: In this article, the role of IONP-loaded bionanocomposites on silver nanoparticles (AgNPs) release and the effect of AgNPs on wound healing by targeting bacterial biofilms has been investigated. For this purpose, articles published in various databases such as PubMed, Google Scholar and Elsevier have been discussed and analyzed.Conclusion: Researchers successfully developed a smart bionanocomposite wound dressing by optimizing the combination of AgNPs, IONPs, and polymers which exhibited significant antimicrobial and antibiofilm properties when subjected to an EMF, making it a promising candidate for wound management in cases involving antibiotic-resistant biofilms. Furthermore, biosynthesized AgNPs-LD nanoparticles are effective antibacterial agents and promising novel wound healing products for clinical applications.

کلیدواژه ها:

Silver nanoparticles ، Bionanocomposites ، Bacterial biofilm