Introduction: Since the skin is the first line of defense and the largest organ of the body, it is necessary to maintain its integrity. In recent decades, healing chronic wounds has emerged as a significant challenge. The use of medicinal plants has a rich historical background in disease treatment and enjoys widespread cultural acceptance in the world. However, the era of allopathic medicine has significantly curtailed their utilization. In East Asian countries, traditional herbal medicine (THM) has been used for centuries. However, recently it has gained attention in developed countries for treating various ailments, including wound healing. As a result, researchers have increasingly focused on evidence-based approaches within this domain. But more information is required regarding certain aspects of them. Therefore, this study reviews the uses of medicinal plants in wound healing. Method: We systematically reviewed PubMed, Scholar, Medline, SID, CINAHL, Scopus, Elsevier, Iran Doc, and Magiran databases. Finally, ۱۵ articles from ۲۰۱۵ to ۲۰۲۳ with an emphasis on the relevant articles of the last five years, were selected. Findings: New research indicates that numerous plants and their extracts possess significant potential in wound management. Phytomedicine also provides herbal medicines that have significant pharmacological effects and have been widely used for healing skin wounds. In studies, THM has been used with the goals of debridement, providing an optimal setting for wound healing and disinfection. Numerous studies have mentioned the potential benefits of medicinal plants, which include antioxidant and anti-inflammatory properties, immune system strengthening, accelerated epithelialization, collagen formation, and angiogenesis promotion. Nevertheless, there are still obstacles, such as inadequate solubility, unfavorable absorption, and low concentration of active components extracted from plants, as well as the presence of unwanted side effects. Conclusion: Currently, medicinal plants have become very popular in developed countries. Medicinal plants possess the potential to serve as a valuable addition or even substitute for modern wound healing treatments, because of their safety, minimal side effects, and ability to enhance wound-healing mechanisms. Nevertheless, there have been limited clinical studies conducted in the realm of various wound types and therapeutic interactions, with a majority of them being carried out on animals.