Skin Wound Tissue Engineering with the Focus on Stem Cell-based Therapeutic Approaches

Normal wound healing is a multiple phase process which requires complex interactions between various cells, cytokine, chemokines and growth factors. Chorionic wounds occur as a result of failure in different healing phases as well as prolonged inflammation. The difficulty of treating these wounds, including high costs and frequent dressing changes, has made it necessary to design more effective therapeutic approaches to guide skin regeneration rather than wound healing. Accordingly, wound tissue engineering has been provided promising therapeutic strategies using cell/stem cells and synthetic/natural polymers. It has shown a great potential for skin tissue regeneration and successful wound healing. Here we will discuss the efficacy of different stem cell types and sources in wound healing as well as various approaches whereby these cells can best demonstrate their unique properties in skin tissue repair. In addition, we will describe existing challenges for using stem cells in skin tissue regeneration.

کلیدواژه ها:

Wound healing ، Mesenchymal stem cells ، Cytokines ، Chronic wounds ، Skin tissue