Investigating the Synergistic Effect of Turmeric and Ferula Gummosa in the Healing of Surgically Induced Gastric Ulcer in Rat

Gastric ulcer is one of the most common digestive problems. The purpose of this study is to investigate the histopathology and serology effect of turmeric and Ferula gummosa extracts in accelerating the healing of gastrotomy wounds in Rats. In this study, ۴۰ adult male Wistar rats were divided into ۵ control groups, omeprazole, turmeric, Ferula gummosa and the combination of turmeric and Ferula gummosa. A ۱cm gastrotomy incision was made between the greater and lesser bends of the stomach and then sutured in ۲ layers in a Cushing pattern. After ۱۴-day gavage period, blood samples were taken to check TNF-α and IL-۶ factors. Also, tissue samples were taken from the gastrotomy sites and after preparing tissue sections, they were stained with hematoxylin-eosin method. The results showed that the combination of turmeric and Ferula gummosa increased the rate of wound healing and compared to the separate use of turmeric and Ferula gummosa extracts, it reduced inflammatory factors to a greater extent and also improved the healing rate of gastrotomy wounds.

کلیدواژه ها:

Turmeric ، Ferula gummosa ، Surgery ، Gastric Ulcer ، Rat ، Healing