For many years, bioreactors have been the focus of attention in the field of biological production due to the ability to provide a controlled environment and the possibility to monitor and even intervene in the required parameters. An ideal bioreactor for tissue engineering, in addition to the ability to effectively regulate various environmental factors (pH, oxygen level, temperature), transport nutrients and remove waste materials, should also provide the ability of sterilization procedures and the possibility of sampling, so that the appropriate cells of the target tissue It is thought that they can be stabilized in porous, biodegradable and biocompatible scaffolds similar to the body environment in a dynamic environment in laboratory conditions for tissue growth. Full-thickness skin grafts by replacing both the dermis and epidermis layers are suitable as an immediate cover for the injury site and can prevent delays in the repair of the injury, and despite the success of these skin grafts, its commercial use in the clinic It is limited for various reasons. The main limitation of the available tissue-engineered dermal substitutes is vascularization. One way to overcome this problem is to use a compatible bioreactor. In studies, bioreactors were used to maintain human skin explants under fluid dynamic conditions in vitro, which had previously been used to successfully maintain skeletal muscle grown invitro. The result of one of these studies was compared with skin samples kept in static conditions in terms of tissue changes and it was found that the samples kept in the bioreactor still show structural integrity after ۷۲ hours. Despite the advantages of using conventional tissue engineering bioreactors for the growth of whole tissue grafts, one of their main limitations is the absence of healthy blood vessels and as a result the disruption of cell and tissue viability. In order to overcome these problems, alternatives called in vivo bioreactors were used, which do not require strong equipment and hardware design.