Evaluation of Thermal Properties of Ferromagnetic Core for Treatment of Solid Tumors by Electromagnetic Induction Hyperthermia

Background: Electromagnetic induction hyperthermia is a promising method to treat the deep-seated tumors such as brain and prostatic tumors. This technique is performed using the induction of electromagnetic waves in the ferromagnetic cores implanted at the solid tumor.Objective: This study aims at determining the conditions of the optimal thermal distribution in the different frequencies before performing the in vitro cellular study.Material and Methods: In this experimental study, the i-Cu alloy (۷۰.۴-۲۹.۶; wt%) was prepared and characterized and then the parameters, affecting the amount of induction heating in the ferromagnetic core, were investigated. Self-regulating cores in ۱, ۳, ۶, and ۹ arrangements in the water phantom with a volume of ۲ cm۳ were used as a replacement for solid tumor.Results: Inductively Coupled Plasma (ICP) analysis and Energy Dispersive X-ray Spectroscopy (EDS) show the uniformity of the alloy after ۴ times remeling by vacuum arc remelting furnace. The Vibrating Sample Magnetometer (VSM) shows that the Curie temperature (TC) of the ferromagnetic core is less than ۵۰ °C. Temperature profile with a frequency of ۱۰۰-۴۰۰ kHz for ۳۰ min, was extracted by infrared imaging camera, indicating the increase temperature in the range of ۴۲ °C to ۴۶ °C. Conclusion: The optimum conditions with used hyperthermia system are supplied in the frequency of ۱۰۰ kHz, ۲۰۰ kHz and ۴۰۰ kHz with ۶, ۳ and ۱ seeds, respectively. It is also possible to induce a temperature up to ۵۰ °C by increasing the number of seeds at a constant frequency and power, or by increasing the applied frequency at a constant number of seeds.

کلیدواژه ها:

Hyperthermia ، Electromagnetic Fields ، Ni-Cu Ferromagnetic Core ، Solid Tumor ، Water Phantom ، Alloys