Proton Magnetic Resonance Spectroscopy to Detect Correlations between Clinical Symptoms and Brain Metabolite Levels in Patients with Tension-type Headache
محل انتشار: مجله فیزیک و مهندسی پزشکی، دوره: 10، شماره: 5
سال انتشار: 1399
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 57
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شناسه ملی سند علمی:
JR_JBPE-10-5_007
تاریخ نمایه سازی: 30 دی 1402
چکیده مقاله:
Background: Proton magnetic resonance spectroscopy (۱HMRS) is a noninvasive method to quantify pain. A ۱HMRS spectrum is a group of peaks at different radiofrequencies, showing proton nuclei in various chemical environments. These MR spectra provide information about metabolite concentrations, and make MRS a useful procedure to monitor metabolic fluctuations due to disease, and to track the efficacy of treatment. Objective: This study aims to identify correlations between clinical symptoms in patients with tension-type headache (TTH) and concentrations of brain metabolites.Material and Methods: In this observational study, twenty-four patients (۴ men and ۲۰ women) with chronic TTH were included. To evaluate their clinical symptoms, the number of trigger points, headache frequency and headache intensity were recorded. The levels of anxiety and depression were recorded with the Beck Anxiety Inventory (BAI) and Beck Depression Inventory II (BDI- II). Concentrations of brain metabolites were determined in the anterior cingulate cortex, thalamus and primary somatosensory cortex of left hemisphere with ۱HMRS. Results: There was a negative correlation between trigger point count and choline/creatine (Cho/Cr) ratio in the primary somatosensory cortex [r= −۰.۵۰۹, n= ۲۴, p = ۰.۰۱]. There were no correlations between other clinical symptoms of TTH and concentrations of brain metabolites. Conclusion: Patients with more trigger points had a lower Cho/Cr ratio, which may indicate alterations in brain metabolic activity.
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نویسندگان
M Mohamadi
PhD, Student Research Committee, Department of Physical Therapy, School of Rehabilitation Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
Z Rojhani-Shirazi
PhD, Rehabilitation Research Center, Department of Physical Therapy, School of Rehabilitation Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
R Asadsangabi
PhD, Department of Radiology, Davis School of Medicine, University of California, USA
A Rahimi-Jaberi
PhD, Department of Neurology, School of Medicine,Shiraz University of Medical Sciences, Shiraz, Iran
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