Gamma-Glutamyl Transferase and the Risk of Type ۲ Diabetes Mellitus: A Review

The relationship between gamma-glutamyl transferase (GGT) levels and risk factors for type ۲ diabetes mellitus (T۲DM) and the risk of incident T۲DM was assessed using a narrative review of available evidence. Higher circulating levels of GGT are associated with an increased risk of type ۲ diabetes mellitus, suggesting GGT as a risk predictor of T۲DM. The incidence of type ۲ diabetes and its association with GGT elevation could be explained by oxidative stress in cells followed by subclinical inflammation and fatty liver, leading to impaired insulin secretion and insulin resistance. A strong correlation is evident between BMI and GGT, in which hepatic steatosis and insulin resistance are proposed to be the intermediate connecting characteristics.

کلیدواژه ها:

Gamma-glutamyl transferase ، Type ۲ diabetes mellitus ، Body mass index