The relationship between lipid profile after fat loading and coronary artery disease severity assessed by SYNTAX score

BACKGROUND: Dyslipidemia is an established risk factor for coronary artery disease (CAD). Despite this, only half of CAD patients present with fasting dyslipidemia. Some reports have linked postprandial lipemia to atherosclerosis. We aimed to test the relationship between postprandial lipid profile (after fat loading) and CAD severity assessed by the SYNTAX score.METHODS: We included ۵۳ patients with documented CADs. We checked both fasting and postprandial (۲ hours) lipograms after fat loading with ۱۷ g/body surface area (m۲). Then we assessed CAD severity via coronary angiography using the SYNTAX score. Our study is registered in clinicaltrials.gov (NCT۰۳۱۷۵۳۹۳).RESULTS: *۵۳ patients with age ۵۷.۹۲ ± ۷.۸۲ were recuirted. ۳۶ (۶۸% ) of them were male .We observed a significant increase in postprandial triglycerides (TGs); TGs (۱۵۴.۳۰ ±۷۳.۲۳ vs. ۱۲۸.۰۷ ± ۶۹.۴۰ mg/dl; P < ۰.۰۰۱), very-low-density lipoproteins (VLDL) (۳۰.۸۵ ± ۱۴.۶۵ vs. ۲۵.۶۰ ± ۱۳.۹۳ mg/dl; P < ۰.۰۰۱) as well as a significant decrease in the postprandial level of total cholesterol (۱۶۲.۳۷ ± ۴۵.۸۶ vs. ۱۶۸.۲۶ ± ۴۵.۹۶ mg/dl; P = ۰.۰۳) in comparison to their fasting level.We found that the SYNTAX score had a significant positive moderate correlation with ۲-hour postprandial TGs (r = ۰.۵۵; P < ۰.۰۰۱) and ۲-hour postprandial VLDL (r = ۰.۵۰; P < ۰.۰۰۱). Based on the current study, predictors of high Syntax score were older age OR: ۱.۲۳( ۱.۱۱-۳.۴۷); P< ۰.۰۰۱, post-prandial triglyceride OR: ۲.۳۴ (۱.۸۹-۵.۶۶); P< ۰.۰۰۱ and post-prandial VLDL OR: ۱.۷۶( ۱.۵۰-۳.۴۹); P< ۰.۰۰۱CONCLUSION: Postprandial lipograms, especially TGs, are significantly and positively related to CAD severity.

کلیدواژه ها:

Total cholesterol ، lipogram ، Postprandial lipogram ، SYNTAX score ، Triglycerides