Evaluation of effect of tween ۸۰ on characteristics of tadalafil ۰.۱% suspension

سال انتشار: 1394
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 98

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شناسه ملی سند علمی:

JR_PBRE-1-2_005

تاریخ نمایه سازی: 10 دی 1402

چکیده مقاله:

Tadalafil is a phosphodiesterase ۵ inhibitor used orally as solid dosage form. The suspension of this drug has been used for pulmonary arterial hypertension treatment in pediatrics. The aim of this work was to investigate the influence of non-ionic surfactant (Tween ۸۰) on the physical characteristics, drug particle size, and stress-shear rate rheogram of tadalafil ۰.۱% suspension. Several formulations prepared by xanthan gum as suspending agent. Glycerin has been used as wetting agent. The several amounts of Tween ۸۰ were added and the characteristics of suspensions were evaluated during ۶ months. The results showed the effect of surfactant on sediment volume and resuspendibility. The particle size of tadalafil was affected by surfactant amount. This result showed an optimum effect of Tween ۸۰ on drug particle size. The viscosity behavior evaluation of tadalafil ۰.۱% suspension showed Tween ۸۰ effect. This study showed that Tween ۸۰ can dramatically affect viscosity of suspensions. The results of this study have demonstrated the effect of Tween ۸۰ on physical properties of tadalafil ۰.۱% oral suspension. An ideal drug particle size was observed in particular amount of Tween ۸۰ (۰.۱۵% w/v).

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نویسندگان

Majid Saeedi

Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran

Mohammad Reza Rafati

Department of Clinical Pharmacy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran

Katayoun Morteza-Semnani

Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran

Atieh Yazdani Rostam

Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran

Hamid Reza Kelidari

Pharmaceutical Sciences Research Centre, Mazandaran University of Medical Sciences, Sari, Iran

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