Evaluation of prophylactic antibiotic administration in general surgery division of a teaching hospital in north of Iran

Surgical site infections are one of the most important post-surgery complications. Antimicrobial prophylaxis has been used routinely in surgeries to reduce infection incidence. However, inappropriate selection of antimicrobial agents or dosing can develop antimicrobial resistance, serious adverse reactions and prolong hospitalization. Current study aimed to examine prophylactic antibiotic prescription in surgeries in a teaching hospital in Sari, Mazandaran and evaluate level of adherence to the international guidelines. Between January ۲۰۱۵ to May ۲۰۱۵, ۱۰۴ patients in general surgery ward were selected and enrolled in the study. The prophylactic antibiotics, dosage, timing and duration of administration were collected by reviewing patients’ records and compared to the existing guidelines. Prophylactic antibiotic was given to ۸۵.۵% of patients. Prescribed antibiotics were cefazolin (۴۶.۱%), metronidazole (۲۴%), ceftriaxone (۱۲.۵%), ciprofloxacin (۱.۹%) and vancomycin (۰.۹۶%). Most of the patients (۶۲.۹%) received an inappropriate and delayed timing. Proper antibiotic dosage was seen in ۴۵.۲% of patients. All patients received post-operative prophylactic antibiotic. Main antibiotics include cefazolin (۴۱.۳%), metronidazole (۳۳.۷%), ceftriaxone (۳۱.۷%) and clindamycin (۲۰.۲%). Only ۱۰ (۲۱.۹%) patients received cefazolin or vancomycin for a total duration of ۴۸ hours or less. Surgical wound infection occurred in ۱۷ (۱۶.۳%) patients during hospital stay. Adherence to antimicrobial prophylaxis guidelines was completely achieved in ۱۴.۴% of cases. Results of this study signified that adherence to existing guidelines was poor and the most common mistakes were over usage, inappropriate dosage and choosing of antibiotics.

کلیدواژه ها:

Antimicrobial prophylaxis ، general surgery ، guideline