Protective effect of selenium against aluminium chloride induced cardiotoxicity in rats

Our study pertains to evaluate the protective effect of selenium (Se), used as a nutritional supplement, against aluminium chloride induced cardiotoxicity in rats. Rats have received during ۲۱ days either AlCl۳ (۴۰۰ ppm) via drinking water, AlCl۳ associated with Na۲SeO۳ (۰.۵ mg/kg of diet) or only Na۲SeO۳. Co-administration of Se to AlCl۳ treated rats alleviated heart oxidative stress objectified by a decrease of malondialdehyde, hydrogen peroxide and protein carbonyls levels. An improvement in antioxidant redox status, enzymatic (catalase, superoxide dismutase and glutathione peroxidase) and non enzymatic (reduced glutathione, non protein thiols and vitamin C) was also observed in Se treated rats.  LDH and CK activities, TC, LDL-C levels, TC/HDL-C and LDL-C/HDL-C ratios were increased, while HDL-C and TG decreased in rats treated with AlCl۳. Cardiac biomarkers and lipid profile were restored to near control values by the supplementation of Se. Our results revealed that Se, a trace element with antioxidant properties, was effective in preventing heart damage induced by aluminium chloride.

کلیدواژه ها:

Aluminium ، rats ، oxidative stress ، selenium ، heart