Effectiveness of ۵-aminolevulinic Acid Combined with Curcumin Mediating Photodynamic Therapy

۵-aminolevulinic acid (۵-ALA) is the mitochondria metabolite produced from glycine and succinyl-CoA, which is converted to protoporphyrin IX (PpIX) by the conjugation of eight itself molecules forming the “heme” group in a porphyrin ring (Figure ۱) [۱]. The PpIX is used as a photosensitizer (PS) with an absorption wavelength of ۴۱۰ nm, and ۵-ALA acts as a precursor or prodrug for PpIX in photodynamic therapy (PDT). Exogenous administration of excessive amounts of ۵-ALA increases the production of PpIX during heme biosynthesis. It is eliminated after ۲۴-۴۸ h with a lower risk of long-term photosensitivity [۲]. However, ۵-ALA PDT has several disadvantages, including the concentration of ALA is affected by its absorption and pharmacokinetics that are not fully covered the treatment area [۳-۵], as well as the limited depth of tumor penetration and caused pain symptoms [۶].

کلیدواژه ها:

۵-Aminolevulinic Acid ، Photosensitizer ، Photodynamic therapy ، Curcumin